ArtioSense is a spin-out from the University of Cambridge that seeks to commercialise a novel, conformable force sensing technology for applications in orthopaedic surgery, sports medicine and beyond.
ArtioSense was born out of a desire to solve force sensing challenges in precision orthopaedic surgery. Improper force balancing during joint replacement surgery is a major cause of implant wear and premature failure, which necessitates complex and difficult revision surgery. This is of course distressing for patients, severely impacting their quality of life. It also places further burdens on already overstretched public health systems.
Solving this challenge requires sensors that can measure the large forces passing through weight-bearing joints, while still being thin and conformable to facilitate their use in curved geometries such as the hip. Leveraging state-of-the-art additive manufacturing techniques, the ArtioSense team has invented a microfluidic force sensor (patent pending) that addresses this unmet clinical need in a highly robust manner.
The microfluidic sensor is thin, conformable, robust and capable of measuring a wide range of forces in different settings. A paper describing the underlying technology has been published in Cell Reports Physical Science, with follow up publications in preparation describing various different applications of the technology. We are in the process of conducting pre-clinical trials of the technology, following which we will plan first-in-human trials of the sensors as the next step of our translational pathway.
Our core team spans a wide range of expertise, from clinical medicine to the biological and physical sciences.
ArtioSense epitomizes the cross-disciplinary nature of modern-day R&D. Emerging from conversations that spanned the domains of materials science, biophysics and surgical practice, the technology perfectly showcases the value of interdisciplinary collaborations fostered by Cambridge.
Our technology is built on years of research, and has been validated by our peers in the academic community.
Q. Jing, A. Pace, L. Ives, A. Husmann, N. Catic, V. Khanduja, J. Cama* and S. Kar-Narayan*. Cell Reports Physical Science (2) 2021 100386.
N. Catic, L. Wells, K. Al Nahas, M. Smith, Q. Jing, U.F. Keyser, J. Cama* and S. Kar-Narayan*. Applied Materials Today (19) 2020 100618.
Our latest manuscript describing the ArtioSense sensors and their use in the hip implant prosthesis is online as a preprint on bioRxiv, Conformable and robust force sensors to enable precision joint replacement surgery
Our co-founder Vikas Khanduja is featured in an article in The Cambridge Independent, Tackling a clinical research challenge in Cambridge amid the pandemic
Our co-founder Dr. Sohini Kar-Narayan has been recognised as one of the top 50 Women in Engineering 2021!
Cambridge Science Festival 2021 Wireless Finger Force Sensor.
The video below shows a conformable microfluidic capacitive force sensing device attached to a finger cot as a sensitive wireless pressure sensor. Forces on the finger cot can be read off wirelessly in real time on a handheld mobile device.
Our paper describing the sensor technology underpinning ArtioSense has been published in Cell Reports Physical Science!
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Sohini is a Reader (Associate Professor) in Device & Energy Materials at the Department of Materials Science at the University of Cambridge, where she leads a research group specialising in functional nanomaterials for energy, sensing and biomedical applications. She is a co-inventor of ArtioSense’s core technology. She works closely with clinicians, surgeons and med-tech companies to find materials and device-based solutions to existing problems.
Vikas is a Consultant Orthopaedic Surgeon in Addenbrooke’s, Cambridge University Hospital specialising in both sports surgery and arthroplasty aspects of hip and knee surgery and has a particular interest in arthroscopic surgery of the hip. He has been instrumental in setting up the tertiary referral service for Young Adult Hip Surgery in Cambridge. He is the co-inventor of ArtioSense’s core technology and is leading on the translational aspect of the use of this technology in orthopaedics and sports medicine.
Jehangir is a biophysicist who specialises in the development and use of microfluidic technologies for quantitative biology and biosensing. He obtained his PhD from Trinity College and the Cavendish Laboratory at the University of Cambridge. He has leveraged microfluidics to tackle a range of problems, including in antimicrobial research and development. He is a co-inventor of ArtioSense’s core technology, and is presently an Industry Research Fellow at the Living Systems Institute, University of Exeter.
Alex is co-founder of ArtioSense and responsible for the multidisciplinary development and translatability of its technology. He currently works as a Translational Technology Manager at the University of Cambridge (School of Clinical Medicine). He has previous experience in world class biomedical research laboratories (i.e. at the NIH, USA; UNC, USA and McGill University, Canada), where he mastered projects spanning basic, translational and drug discovery science.